| NCAAF | 11/11 20:00 | 1 | Missouri Southern Lions v Missouri Western Griffons | W | 47-41 | |
| NCAAF | 11/04 18:00 | 1 | Emporia State v Missouri Southern Lions | L | 63-28 | |
| NCAAF | 10/28 19:00 | 1 | Missouri Southern Lions v Central Missouri Mules | L | 21-42 | |
| NCAAF | 10/21 19:00 | 1 | Blue Tigers v Missouri Southern Lions | W | 5-63 | |
| NCAAF | 10/14 19:00 | 1 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 | |
| NCAAF | 10/07 19:00 | 1 | Missouri Southern Lions v Fort Hays State University Tigers | L | 22-35 | |
| NCAAF | 09/30 19:00 | 1 | Сентрал Оклахома v Missouri Southern Lions | L | 30-27 | |
| NCAAF | 09/23 19:00 | 1 | Missouri Southern Lions v Northeastern State Riverhawks | W | 42-0 | |
| NCAAF | 09/16 17:00 | 1 | Небраска Кеарней v Missouri Southern Lions | W | 13-18 | |
| NCAAF | 09/07 23:00 | 1 | Washburn Ichabods Football v Missouri Southern Lions | W | 23-30 | |
| NCAAF | 09/01 00:00 | 1 | Missouri Southern Lions v NW Missouri State | L | 24-31 | |
| NCAAF | 11/12 20:00 | 1 | Missouri Southern Lions v Washburn Ichabods Football | L | 20-37 |